Quick Answer: Why Is My Varicella Titer Negative?

What is a high titer level?

The greater the concentration of the specific antibody in the serum sample, the higher the titer.

For example, a titer for an influenza hemagglutination inhibition assay of 1:10 would be very low; a titer of 1:320 would be high.

A low or undetectable titer indicates very little antibody present in the serum..

How do you prove varicella immunity?

According to ACIP, acceptable evidence of varicella immunity in healthcare personnel includes (1) documentation of 2 doses of varicella vaccine given at least 28 days apart, (2) history of varicella or herpes zoster based on clinician diagnosis, (3) laboratory evidence of immunity, or (4) laboratory confirmation of …

What is a normal varicella titer?

0.90 ISR or less: Negative – No significant level of detectable varicella-zoster virus IgM antibody. 0.91-1.09 ISR: Equivocal – Repeat testing in 10-14 days may be helpful. 1.10 ISR or greater: Positive – Significant level of detectable varicella-zoster virus IgM antibody. Indicative of current or recent infection.

What does a positive varicella titer test mean?

Establishing Laboratory Evidence of Immunity to Varicella A positive IgG ELISA result indicates that a person has antibodies to VZV either from past varicella disease or vaccination. This test cannot distinguish whether the antibodies were from a past episode of varicella or vaccination.

What does a varicella titer show?

Varicella Titer (or VZV titer or varicella antibody titer test) is another type of testing process that is used for checking the concentration of IgM and IgG antibodies in the blood. In other words, it is a blood test for chickenpox antibodies.

What does positive titer mean?

Titers are blood tests that check your immune status to vaccinations or diseases you may have received in the past. If you’re titers results are positive, it means that you have adequate immunity to a particular infectious disease. Therefore, you do not need to get that particular vaccine.

What happens if my hep B titer is negative?

If the anti-HBs is positive (10 mIU/mL or higher), she is immune. No further action is needed other than to document the results. If the anti-HBs is still negative, complete the vaccine series and test again 1–2 months after the last dose of vaccine.

What if my measles titer is negative?

Single antigen vaccine is no longer available in the U.S.; the student should get the combined MMR vaccine. If a college student or other person at increased risk of exposure cannot produce written documentation of either immunization or disease, and titers are negative, they should receive two doses of MMR.

Do varicella titers want positive or negative?

A positive IgG result coupled with a negative IgM result indicates previous vaccination to or infection with VZV. These individuals are considered to have protective immunity to reinfection. A negative IgG result coupled with a negative IgM result indicates the absence of prior exposure to VZV and nonimmunity.

Why are my titers negative?

If your titers are negative, then you may need to start the vaccination series over or have a booster shot.

What is a normal titer level?

The normal values of an antibody titer depend on the type of antibody. If the testing is done to detect autoantibodies, the normal value should essentially be zero or negative. In the case of testing the efficacy of a vaccine, the normal test result depends on the definite value that is specific for that immunization.